Protein Loss

Protein-losing enteropathy (PLE) is a rare complication of a variety of intestinal disorders characterized by an excessive loss of proteins into the gastrointestinal tract due to impaired integrity of the mucosa. The disorders causing PLE can be divided into those due to protein loss from intestinal lymphatics, like primary intestinal lymphangiectasia or congenital heart disease and those with protein loss due to an inflamed or abnormal mucosal surface. 

(Reference credits: Braamskamp MJ, Dolman KM, Tabbers MM. Department of Pediatrics, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands.)

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